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MMP's

 
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twmdds



Joined: 16 May 2006
Posts: 142

PostPosted: Thu Jul 27, 2006 5:44 pm    Post subject: MMP's Reply with quote

Hi John!
I get too much crap at DT when I ask stupid questions so I'll ask it here and hope to get less. What are MMP's? Is this important?
Tom
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Ekrause



Joined: 11 May 2005
Posts: 782
Location: I'm here now.

PostPosted: Thu Jul 27, 2006 7:43 pm    Post subject: Reply with quote

I'm pretty sure they're Matrix Metalloproteinase's
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twmdds



Joined: 16 May 2006
Posts: 142

PostPosted: Thu Jul 27, 2006 8:01 pm    Post subject: Reply with quote

I'll bite! Must have something to do with dentin bonding, but what???
Tom
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Ekrause



Joined: 11 May 2005
Posts: 782
Location: I'm here now.

PostPosted: Thu Jul 27, 2006 8:03 pm    Post subject: Reply with quote

Dentin enzymes that are thought to contribute to the breakdown of the resin-dentin bond long term.
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john kanca



Joined: 14 May 2005
Posts: 6345

PostPosted: Thu Jul 27, 2006 11:01 pm    Post subject: Reply with quote

That's correct.

It is hypothesized tht MMP's are activated by low pH's but inactivated by materials with a pH of 1 or less. They are thought to degrade dentin bonds over time.

I do not know for sure whether this is a fact, but if it is it is my favor, as Simplicity 1 has a pH of 0.6.

David (Pashley) feels pretty strongly about it.
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twmdds



Joined: 16 May 2006
Posts: 142

PostPosted: Fri Jul 28, 2006 12:06 pm    Post subject: Reply with quote

Thanks for the info. I'm am having good results with Simplicity 1 and 2. I used Bisco's Aqua Prep F and One Step Plus from 1999 until a few months ago. Never had sensitivity or debonding problems with them, but lately I've noticed some staining or ditching at the enamel margins. I've always used pulse curing and have seen only a few of the dreaded "white lines". I have noticed that with Simplicity I'm rarely seeing white lines, so I'm hopeful that the ditching will decrease.
Tom
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